The role of nonhistone lactylation in disease

The role of nonhistone lactylation in disease

Blog Article

In 2019, a novel post-translational modification termed lactylation was identified, which established a connection among lactate, transcriptional regulation and epigenetics.Lactate, which is traditionally viewed as a metabolic byproduct, is now model 1840 light artillery saber recognized for its significant functional role, including modulating the tumor microenvironment, engaging in signaling and interfering in immune regulation.While research on lactylation (KLA) is advancing, the focus has primarily been on histone lactylation.This paper oljelampe aims to explore the less-studied area of nonhistone lactylation, highlighting its involvement in certain diseases and physiological processes.

Additionally, the clinical relevance and potential implications of nonhistone lactylation will be discussed.